Masturbation side effects Frequent masturbation and ejaculation stimulate acetylcholine/ parasympathetic nervous functions. Excessive stimulation can result in over production of sex hormones and neurotransmitters such as dopamine, acetylcholine and serotonin. Abundant and unusually large amount of these hormones and neurotransmitters can cause the brain and adrenal glands to perform excessive dopamine-norepinephrine-epinephrine conversion and turn the brain and body functions to be highly sympathetic. Paraphrasing: A significant change of body chemistry occurs when one masturbates excessively. Such side effects of Masturbation include lower back pain, fatigue, thinning hair or hair loss, a soft or weak erection, premature ejaculation, fuzzy vision, groin- or testicular pain and pains or cramps in the pelvic area or tail bone. Bad effects of excessive masturbation is called Sexual Exhaustion, distressing liver- and nervous system functions, and includes youthful impotence/erectile dysfunction (including a soft or weak erection) and seminal leakage. Semen leakage is a sign that the parasympathetic nerve - which keeps the ejaculation valve shut and holds the erection - is weakening as a result of over-masturbation. With a weakened nerve, maintaining an erection is a problem. Another danger of masturbation is skin irritation, and in some cases of bad hygiene, residual body juices can cause fungal infection due to their glucose-content.